To investigate the comprehensive impact of organic-inorganic fertilizer blending on wheat growth, yield formation, and soil quality, with the aim to develop a scientifically sound optimal fertilization regimen tailored for local wheat production that promotes efficient reduction in chemical fertilizer usage while enhancing its effectiveness. 5 distinct treatments were established: the control group (CK), conventional inorganic fertilizer application, a treatment where chemical fertilizer was reduced by 20% combined with organic fertilizer application, another where chemical fertilizer was decreased by 40% in conjunction with organic fertilizer use, and a scenario where chemical fertilizer was diminished by 60% along with organic fertilizer supplementation. These treatments were evaluated through field plot experiments. The results elucidated that the varying effects of different proportions of blended organic and inorganic fertilizers on wheat plant growth characteristics, ultimate yield performance, and soil properties. Notably, the treatment where chemical fertilizer application was reduced by 20% and complemented with organic fertilizer demonstrated the highest wheat yields (8 910 kg/hm²) among all treatments. Compared to exclusive use of chemical fertilizers, the judicious combination of organic and inorganic fertilizers not only significantly enhanced the growth and high-yielding potential of wheat but also effectively improved and optimized soil quality, thus illustrating favorable ecological and economic benefits in agricultural practice.