To explore the effects of ethanol extract from Dendrobium officinale on the gut microbiota of antibiotic induced dysbiosis mice, a blank group and a gut microbiota dysbiosis model group（gavage of lincomycin hydrochloride 120 mg/kg）were set up, respectively. The model group was treated with normal water, high（6 g/kg）and low dose（1.5 g/kg）of ethanol extract from Dendrobium officinale, and the effects of each treatment on the general condition, TNF-α, IL-1 levels, short chain fatty acid levels, gut microbiota composition, richness, and diversity of mice were observed. The results showed that the general mental condition of mice in the high-dose and low-dose groups of Dendrobium officinale improved, and the levels of serum TNF-α and IL-1 were significantly reduced compared to the model group, while the levels of short chain fatty acids were significantly increased. There were differences in the species composition of gut microbiota compared to the model group, but no significant differences in richness and diversity. The ethanol extract of Dendrobium officinale had a certain improvement effects on the gut microbiota of antibiotic induced intestinal dysbiosis mice.
ZHU Can
,
XU Xiaoyu
,
LI Jun
,
LIU Junjie
,
GU Fangli
,
HUANG Renshu
,
HE Xiaomei
. Effects of the ethanol extract of Dendrobium officinale on gut microbiota of dysbacteriosis mice[J]. Anhui Agricultural Science Bulletin, 2024
, 30(15)
: 46
-50
.
DOI: 10.16377/j.cnki.issn1007-7731.2024.15.011
[1] 仲益. 药学干预对抗生素临床合理应用的影响[J]. 北方药学,2021,18(6):102-103.
[2] 洪关婷,梁磊,王一琼,等. 中药调节肠道微生态治疗抗生素相关性腹泻的研究进展[J]. 中国肛肠病杂志,2023,43(11):76-80.
[3] 黄怡秋,许春娣,王歆琼,等. 双歧杆菌三联活菌散/胶囊治疗儿童抗生素相关性腹泻临床疗效的meta分析[J]. 中国微生态学杂志,2023,35(9):1032-1038.
[4] 李昕,曾洁,王岱,等. 细菌耐药耐受性机制的最新研究进展[J]. 中国抗生素杂志,2020,45(2):113-121.
[5] 宋媛媛,贡雪芃,肖蒙,等. 抗生素相关性腹泻研究进展[J].医药导报,2019,38(11):1454-1458.
[6] 韩天雨,杨栋,周树青,等. 抗生素所致肠道菌群失调与治疗研究进展[J]. 解放军预防医学杂志,2021,39(1):98-101.
[7] 林丽,谷翠红,王硕,等. 短链脂肪酸对抗生素相关性腹泻的作用及机制研究[J]. 实用临床医药杂志,2023,27(19):61-66.
[8] 杨欢. 中草药对肠道菌群的影响及对T2 DM小鼠肠道菌群和糖代谢的影响[D]. 大连:大连医科大学,2022.
[9] 王治丹,代云飞,罗尚娟,等. 铁皮石斛化学成分及药理作用的研究进展[J]. 华西药学杂志,2022,37(4):472-476.
[10] 杨丽婷,王子微,王加启,等. 短链脂肪酸及其调节肠道炎症作用的研究进展[J]. 食品工业科技,2022,43(24):433-443.
[11] 杨艳青,李灿委,杨自忠,等. 肠道菌群代谢物:短链脂肪酸的研究进展[J]. 实用医学杂志,2022,38(14):1834-1837.
[12] 郭春艳,刘雪梅,李艾洵,等. 健脾益肾通络方对MPTP诱导的帕金森病小鼠肠道菌群与短链脂肪酸的调节作用[J]. 中国微生态学杂志,2024,36(1):1-9.
[13] 高双双,王渟,范华宇,等. 肠道菌群失调与银屑病的相关性研究进展[J]. 中国中西医结合皮肤性病学杂志,2022,21(6):566-569.
[14] 欧阳晓俊. 肠道菌群与代谢性疾病的研究进展[J]. 中国临床保健杂志,2021,24(3):305-310.
[15] 吴仪,谭周进. 代谢性疾病肠道菌群研究现状及其与中医诊疗关系的探讨[J]. 中国微生态学杂志,2021,33(6):718-722.
[16] 张小芳,王欣,汪惠勤,等. 人体肠道菌群代谢氨基酸产生短链脂肪酸及对细胞通透性的影响[J]. 中国食品学报,2021,21(7):60-67.
[17] 张学强,章从恩,于小红,等. 干姜改善抗生素相关性腹泻及对肠道菌群的作用研究[J]. 中国中药杂志,2022,47(5):1316-1326.
[18] 孙乐,陈晓梅,吴崇明,等. 铁皮石斛多糖药理活性研究进展[J]. 药学学报,2020,55(10):2322-2329.
[19] 于子真,谭周进,肖嫩群. 铁皮石斛对脾虚便秘小鼠肠道形态及肠道免疫细胞数量的影响[J]. 食品安全质量检测学报,2021,12(8):3224-3228.
[20] 倪凯,何鹏飞,梁志庆,等. 铁皮石斛化学成分、药理作用及毒理学评价研究进展[J]. 云南中医中药杂志,2023,44(10):86-93.
[21] 陈文华,李思琦,宋佳,等. 铁皮石斛对抗生素诱导小鼠肠道菌群紊乱的改善作用[J]. 中草药,2023,54(19):6362-6369.
