In order to screen for highly effective, safe, and excellent chemical agents and application methods, during the critical period for the control of scab, commonly used wheat scab control agents were selected from the market, and a comparative trial of wheat scab control efficacy was conducted using two application methods. The results showed that for the selection of control agents, any one of the following could be used: 20% fluxapyroxad SC 750 mL/hm²+ 25% propiconazole EC 600 mL/hm², 40% prothioconazole·tebuconazole SC 600 mL/hm², 30% prothioconazole OF 900 mL/hm²+43% tebuconazole SC 600 mL/hm², 30% dimethomorph·tebuconazole SC 600 mL/hm², or 70% thiophanate-methyl WP 1 500 g/hm². In terms of application equipment, when considering only the application effect, the efficacy of using a knapsack electric sprayer was superior to that of using a multi-rotor plant protection drone. However, taking into account factors such as labor, operational efficiency, and timing of control, appropriate method could be choosed based on its actual circumstances. The purpose was to provide a reference for the scientific prevention and control of wheat scab.