To screen high yield and high quality hybrid rice varieties suitable for planting in the Chizhou region of Anhui Province, a trial was conducted on 20 hybrid rice varieties, including Quanyou 5438, Fliangyou 1252, and Wuliangyouyuzhan. The growth period, plant vigor, resistance, yield, and yield components of the varieties were analyzed. The results showed that the full growth period of the tested varieties ranged from 132 to 141 days. Among them, Wuliangyouyuzhan, Tailiangyouxiangwu, Liangyou 517, and Jiuliangyou No.9 exhibited moderate growth vigor, while the others showed vigorous growth. All varieties demonstrated strong lodging and disease resistance. In terms of yield and yield components, plant height ranged from 97.8 to 123.2 cm, effective panicles per hectare from 2.035 to 3.192 million/hm², total grains per panicle from 179.1 to 320.3, grain density from 7.6 to 12.8 grains/cm, seed-setting rate from 72.0% to 93.0%, and 1 000-grain weight from 19.6 to 26.6 g. Notably, Liangyou 1976, Xiangliangyou 998, Jiuliangyousimiao, Quanliangyou 532, and Ningliangyou 1513 achieved higher yields of 12.2, 12.1, 12.0, 11.9, and 11.9 t/hm², respectively.In conclusion, Liangyou 1976, Xiangliangyou 998, Jiuliangyousimiao, Quanliangyou 532, and Ningliangyou 1513 exhibited suitable growth periods, moderate plant height, vigorous growth, well-balanced yield structure, strong adaptability, disease resistance, and stress tolerance. The trial results provide a reference for the introduction and production of hybrid rice varieties in the related regions.