To explore efficient and scalable foliar resistance control agents in rice production, 4 foliar inhibitors (potassium fulvic acid, silicon fertilizer, zinc fertilizer, and selenium fertilizer) were selected to investigate its effects on rice growth and yield, as well as the effect of accumulation and transport of cadmium in various organs of rice. The results showed that after spraying four foliar inhibitors during the tillering and grain filling stages of rice, the plant height, tiller number, and thousand grain weight of rice increased to varying degrees. Compared with the blank control, the yield of rice treated with foliar inhibitors increased by 0.34% to 4.83%. After the application of foliar inhibitors, the cadmium content in the roots, stems, leaves, and grains of rice decreased, and the cadmium content in all treated grains met the national food safety standards. Based on the comprehensive analysis of rice yield and cadmium reduction effect, it is recommended to adopt foliar spraying of silicon fertilizer technology in mildly cadmium polluted rice fields to control the absorption and transport of cadmium in rice and achieve safe rice production.